5OU2

M. thermoresistible IMPDH in complex with IMP and Compound 2 (NMR744)

5OU2 の概要

• エントリーDOI: 10.2210/pdb5ou2/pdb
• 分子名称: Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase, INOSINIC ACID, 4-(4-bromophenyl)-1H-imidazole, ... (4 entities in total)
• 機能のキーワード: complex, fragment, impdh, oxidoreductase
• 由来する生物種: Mycobacterium thermoresistibile (strain ATCC 19527 / DSM 44167 / CIP 105390 / JCM 6362 / NCTC 10409 / 316); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40648.82

構造登録者

Ascher, D.B.,Pacitto, A.,Blundell, T.L. (登録日: 2017-08-23, 公開日: 2018-03-28, 最終更新日: 2019-10-16)

• 主引用文献: Trapero, A.,Pacitto, A.,Singh, V.,Sabbah, M.,Coyne, A.G.,Mizrahi, V.,Blundell, T.L.,Ascher, D.B.,Abell, C.; Fragment-Based Approach to Targeting Inosine-5'-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis.; J. Med. Chem., 61:2806-2822, 2018; PubMed: 29547284; DOI: 10.1021/acs.jmedchem.7b01622

実験手法

X-RAY DIFFRACTION (1.45 Å)