5OTM

Crystal structure of human MTH1 in complex with O6-methyl-dGMP

5OTM の概要

• エントリーDOI: 10.2210/pdb5otm/pdb
• 分子名称: 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION, ACETATE ION, ... (5 entities in total)
• 機能のキーワード: mth1, inhibitor, complex, hydrolase, nudix, methylated nucleotide, o6-methyl-dgmp
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38057.52

構造登録者

Gustafsson, R.,Henriksson, L.,Jemth, A.-S.,Brautigam, L.,Carreras Puigvert, J.,Homan, E.,Warpman Berglund, U.,Helleday, T.,Stenmark, P. (登録日: 2017-08-22, 公開日: 2018-09-05, 最終更新日: 2024-01-17)

• 主引用文献: Jemth, A.S.,Gustafsson, R.,Brautigam, L.,Henriksson, L.,Vallin, K.S.A.,Sarno, A.,Almlof, I.,Homan, E.,Rasti, A.,Warpman Berglund, U.,Stenmark, P.,Helleday, T.; MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP.; Nucleic Acids Res., 46:10888-10904, 2018; PubMed: 30304478; DOI: 10.1093/nar/gky896

実験手法

X-RAY DIFFRACTION (1.8 Å)