5ORX

Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment

5ORX の概要

• エントリーDOI: 10.2210/pdb5orx/pdb
• 分子名称: Aurora kinase A, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: kinase, allosteric inhibitor, fragment, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31529.15

構造登録者

McIntyre, P.J.,Collins, P.M.,von Delft, F.,Bayliss, R. (登録日: 2017-08-16, 公開日: 2017-11-01, 最終更新日: 2017-11-29)

• 主引用文献: McIntyre, P.J.,Collins, P.M.,Vrzal, L.,Birchall, K.,Arnold, L.H.,Mpamhanga, C.,Coombs, P.J.,Burgess, S.G.,Richards, M.W.,Winter, A.,Veverka, V.,Delft, F.V.,Merritt, A.,Bayliss, R.; Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.; ACS Chem. Biol., 12:2906-2914, 2017; PubMed: 29045126; DOI: 10.1021/acschembio.7b00537

実験手法

X-RAY DIFFRACTION (1.88 Å)