5ORR
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Summary for 5ORR
Entry DOI | 10.2210/pdb5orr/pdb |
Descriptor | Aurora kinase A, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | kinase, allosteric inhibitor, fragment, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965 |
Total number of polymer chains | 1 |
Total formula weight | 31590.18 |
Authors | McIntyre, P.J.,Collins, P.M.,von Delft, F.,Bayliss, R. (deposition date: 2017-08-16, release date: 2017-11-01, Last modification date: 2017-11-29) |
Primary citation | McIntyre, P.J.,Collins, P.M.,Vrzal, L.,Birchall, K.,Arnold, L.H.,Mpamhanga, C.,Coombs, P.J.,Burgess, S.G.,Richards, M.W.,Winter, A.,Veverka, V.,Delft, F.V.,Merritt, A.,Bayliss, R. Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches. ACS Chem. Biol., 12:2906-2914, 2017 Cited by PubMed: 29045126DOI: 10.1021/acschembio.7b00537 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.09 Å) |
Structure validation
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