5OQ4

PQR309 - a Potent, Brain-Penetrant, Orally Bioavailable, pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology

5OQ4 の概要

• エントリーDOI: 10.2210/pdb5oq4/pdb
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 5-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: pi3k, 3-kinase, lipid kinase, kinase, inhibitor, pqr309, ncb5, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : P48736
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 111359.67

構造登録者

Williams, R.L.,Zhang, X. (登録日: 2017-08-10, 公開日: 2017-09-06, 最終更新日: 2024-01-17)

• 主引用文献: Beaufils, F.,Cmiljanovic, N.,Cmiljanovic, V.,Bohnacker, T.,Melone, A.,Marone, R.,Jackson, E.,Zhang, X.,Sele, A.,Borsari, C.,Mestan, J.,Hebeisen, P.,Hillmann, P.,Giese, B.,Zvelebil, M.,Fabbro, D.,Williams, R.L.,Rageot, D.,Wymann, M.P.; 5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology.; J. Med. Chem., 60:7524-7538, 2017; PubMed: 28829592; DOI: 10.1021/acs.jmedchem.7b00930

実験手法

X-RAY DIFFRACTION (2.7 Å)