5OQ4
PQR309 - a Potent, Brain-Penetrant, Orally Bioavailable, pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology
5OQ4 の概要
エントリーDOI | 10.2210/pdb5oq4/pdb |
分子名称 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 5-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine, SULFATE ION, ... (4 entities in total) |
機能のキーワード | pi3k, 3-kinase, lipid kinase, kinase, inhibitor, pqr309, ncb5, transferase |
由来する生物種 | Homo sapiens (Human) |
細胞内の位置 | Cytoplasm : P48736 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 111359.67 |
構造登録者 | |
主引用文献 | Beaufils, F.,Cmiljanovic, N.,Cmiljanovic, V.,Bohnacker, T.,Melone, A.,Marone, R.,Jackson, E.,Zhang, X.,Sele, A.,Borsari, C.,Mestan, J.,Hebeisen, P.,Hillmann, P.,Giese, B.,Zvelebil, M.,Fabbro, D.,Williams, R.L.,Rageot, D.,Wymann, M.P. 5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology. J. Med. Chem., 60:7524-7538, 2017 Cited by PubMed: 28829592DOI: 10.1021/acs.jmedchem.7b00930 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.7 Å) |
構造検証レポート
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