5OPC

Factor Inhibiting HIF (FIH) in complex with zinc and Vadadustat

5OPC の概要

• エントリーDOI: 10.2210/pdb5opc/pdb
• 分子名称: Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ZINC ION, ... (6 entities in total)
• 機能のキーワード: on-heme, dioxygenase, oxygenase, dna-binding, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, asparaginyl/aspartyl hydroxylase, epigenetic regulation, signaling, ard, beta-hydroxylation, activator-inhibitor, oxidoreductase-peptide complex, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: Q9NWT6
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41728.25

構造登録者

Leissing, T.M.,Schofield, C.J.,Clifton, I.J.,Lu, X.,Zhang, D. (登録日: 2017-08-09, 公開日: 2017-10-18, 最終更新日: 2024-01-17)

• 主引用文献: Yeh, T.L.,Leissing, T.M.,Abboud, M.I.,Thinnes, C.C.,Atasoylu, O.,Holt-Martyn, J.P.,Zhang, D.,Tumber, A.,Lippl, K.,Lohans, C.T.,Leung, I.K.H.,Morcrette, H.,Clifton, I.J.,Claridge, T.D.W.,Kawamura, A.,Flashman, E.,Lu, X.,Ratcliffe, P.J.,Chowdhury, R.,Pugh, C.W.,Schofield, C.J.; Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials.; Chem Sci, 8:7651-7668, 2017; PubMed: 29435217; DOI: 10.1039/c7sc02103h

実験手法

X-RAY DIFFRACTION (2.3 Å)