5OP9
The crystal structure of P450 CYP121 in complex with lead compound 7e
Summary for 5OP9
Entry DOI | 10.2210/pdb5op9/pdb |
Descriptor | Mycocyclosin synthase, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total) |
Functional Keywords | cytochrome p450 inhibitor complex, oxidoreductase |
Biological source | Mycobacterium tuberculosis |
Cellular location | Cytoplasm : P9WPP6 |
Total number of polymer chains | 1 |
Total formula weight | 44829.11 |
Authors | Levy, C.W. (deposition date: 2017-08-09, release date: 2018-03-28, Last modification date: 2024-05-01) |
Primary citation | Taban, I.M.,Elshihawy, H.E.A.E.,Torun, B.,Zucchini, B.,Williamson, C.J.,Altuwairigi, D.,Ngu, A.S.T.,McLean, K.J.,Levy, C.W.,Sood, S.,Marino, L.B.,Munro, A.W.,de Carvalho, L.P.S.,Simons, C. Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation. J. Med. Chem., 60:10257-10267, 2017 Cited by PubMed: 29185746DOI: 10.1021/acs.jmedchem.7b01562 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.455 Å) |
Structure validation
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