5OO0
Cdk2(WT) covalent adduct with D28 at C177
Summary for 5OO0
Entry DOI | 10.2210/pdb5oo0/pdb |
Descriptor | Cyclin-dependent kinase 2, methyl 4-propanoyl-2,3-dihydroquinoxaline-1-carboxylate (3 entities in total) |
Functional Keywords | covalent inhibitor, cysteine modification, kinase, allosteric inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941 |
Total number of polymer chains | 1 |
Total formula weight | 34636.22 |
Authors | Craven, G.,Morgan, R.M.L.,Mann, D.J. (deposition date: 2017-08-04, release date: 2018-03-14, Last modification date: 2024-01-17) |
Primary citation | Craven, G.B.,Affron, D.P.,Allen, C.E.,Matthies, S.,Greener, J.G.,Morgan, R.M.L.,Tate, E.W.,Armstrong, A.,Mann, D.J. High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery. Angew. Chem. Int. Ed. Engl., 57:5257-5261, 2018 Cited by PubMed: 29480525DOI: 10.1002/anie.201711825 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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