5OM2
Crystal structure of Alpha1-antichymotrypsin variant DBS-I1: a drug-binding serpin for doxycycline
Summary for 5OM2
| Entry DOI | 10.2210/pdb5om2/pdb |
| Descriptor | Alpha-1-antichymotrypsin, 1,2-ETHANEDIOL, (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE, ... (5 entities in total) |
| Functional Keywords | serpin, alpha1-antichymotrypsin, protein design, doxycycline-binding protein, transport protein |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 47121.50 |
| Authors | Schmidt, K.,Muller, Y.A. (deposition date: 2017-07-28, release date: 2018-05-23, Last modification date: 2018-06-06) |
| Primary citation | Schmidt, K.,Gardill, B.R.,Kern, A.,Kirchweger, P.,Borsch, M.,Muller, Y.A. Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein. Proc. Natl. Acad. Sci. U.S.A., 115:5744-5749, 2018 Cited by PubMed: 29760101DOI: 10.1073/pnas.1716666115 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.47 Å) |
Structure validation
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