5OM2

Crystal structure of Alpha1-antichymotrypsin variant DBS-I1: a drug-binding serpin for doxycycline

5OM2 の概要

• エントリーDOI: 10.2210/pdb5om2/pdb
• 分子名称: Alpha-1-antichymotrypsin, 1,2-ETHANEDIOL, (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE, ... (5 entities in total)
• 機能のキーワード: serpin, alpha1-antichymotrypsin, protein design, doxycycline-binding protein, transport protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 47121.50

構造登録者

Schmidt, K.,Muller, Y.A. (登録日: 2017-07-28, 公開日: 2018-05-23, 最終更新日: 2024-05-08)

• 主引用文献: Schmidt, K.,Gardill, B.R.,Kern, A.,Kirchweger, P.,Borsch, M.,Muller, Y.A.; Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein.; Proc. Natl. Acad. Sci. U.S.A., 115:5744-5749, 2018; PubMed: 29760101; DOI: 10.1073/pnas.1716666115

実験手法

X-RAY DIFFRACTION (1.47 Å)