5OK8

Crystal structure of protein Lpp20 (HP1456) from Helicobacter pylori

5OK8 の概要

• エントリーDOI: 10.2210/pdb5ok8/pdb
• 分子名称: LPP20 lipoprotein, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: virulence factor; helicobacter pylori; lipoprotein, unknown function
• 由来する生物種: Helicobacter pylori (strain J99 / ATCC 700824)
• 細胞内の位置: Cell outer membrane ; Lipid- anchor : P0A0V1
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 76838.90

構造登録者

Zanotti, G.,Mishra, N.,Valesse, F. (登録日: 2017-07-25, 公開日: 2017-12-06, 最終更新日: 2024-05-08)

主引用文献

Vallese, F.,Mishra, N.M.,Pagliari, M.,Berto, P.,Codolo, G.,de Bernard, M.,Zanotti, G.
Helicobacter pylori antigenic Lpp20 is a structural homologue of Tip alpha and promotes epithelial-mesenchymal transition.
Biochim. Biophys. Acta, 1861:3263-3271, 2017

PubMed Abstract: Helicobacter pylori is a bacterium that affects about 50% of the world population and, despite being often asymptomatic, it is responsible of several gastric diseases, from gastritis to gastric cancer. The protein Lpp20 (HP1456) plays an important role in bacterium survival and host colonization, but the possibility that it might be involved in the etiology of H. pylori-related disorders is an unexplored issue. Lpp20 is a lipoprotein bound to the external membrane of the bacterium, but it is also secreted inside vesicles along with other two proteins of the same operon, i.e. HP1454 and HP1457.

PubMed: 28947343
DOI: 10.1016/j.bbagen.2017.09.017

実験手法

X-RAY DIFFRACTION (1.874 Å)