5ODY
Galectin-3C in complex with dithiogalactoside derivative
Summary for 5ODY
Entry DOI | 10.2210/pdb5ody/pdb |
Descriptor | Galectin-3, 5,6-bis(fluoranyl)-3-[[(2~{R},3~{S},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-[(2~{S},3~{R},4~{S},5~{R},6~{R})-6-(hydroxymethyl)-3,5-bis(oxidanyl)-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxan-2-yl]sulfanyl-3,5-bis(oxidanyl)oxan-4-yl]oxymethyl]chromen-2-one (3 entities in total) |
Functional Keywords | lectin, carbohydrate-binding protein, galactose-specific lectin 3, galactoside-binding protein, galbp, ige-6 binding protein, l-31, laminin-binding protein, lectin l-29, mac-2, sugar binding protein |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P17931 |
Total number of polymer chains | 1 |
Total formula weight | 16434.66 |
Authors | Kumar, R.,Peterson, K.,Nilsson, U.J.,Logan, D.T. (deposition date: 2017-07-07, release date: 2018-05-23, Last modification date: 2024-01-17) |
Primary citation | Peterson, K.,Kumar, R.,Stenstrom, O.,Verma, P.,Verma, P.R.,Hakansson, M.,Kahl-Knutsson, B.,Zetterberg, F.,Leffler, H.,Akke, M.,Logan, D.T.,Nilsson, U.J. Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity. J. Med. Chem., 61:1164-1175, 2018 Cited by PubMed: 29284090DOI: 10.1021/acs.jmedchem.7b01626 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.149 Å) |
Structure validation
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