5ODY

Galectin-3C in complex with dithiogalactoside derivative

5ODY の概要

• エントリーDOI: 10.2210/pdb5ody/pdb
• 分子名称: Galectin-3, 5,6-bis(fluoranyl)-3-[[(2~{R},3~{S},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-[(2~{S},3~{R},4~{S},5~{R},6~{R})-6-(hydroxymethyl)-3,5-bis(oxidanyl)-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxan-2-yl]sulfanyl-3,5-bis(oxidanyl)oxan-4-yl]oxymethyl]chromen-2-one (3 entities in total)
• 機能のキーワード: lectin, carbohydrate-binding protein, galactose-specific lectin 3, galactoside-binding protein, galbp, ige-6 binding protein, l-31, laminin-binding protein, lectin l-29, mac-2, sugar binding protein
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P17931
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16434.66

構造登録者

Kumar, R.,Peterson, K.,Nilsson, U.J.,Logan, D.T. (登録日: 2017-07-07, 公開日: 2018-05-23, 最終更新日: 2024-01-17)

• 主引用文献: Peterson, K.,Kumar, R.,Stenstrom, O.,Verma, P.,Verma, P.R.,Hakansson, M.,Kahl-Knutsson, B.,Zetterberg, F.,Leffler, H.,Akke, M.,Logan, D.T.,Nilsson, U.J.; Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity.; J. Med. Chem., 61:1164-1175, 2018; PubMed: 29284090; DOI: 10.1021/acs.jmedchem.7b01626

実験手法

X-RAY DIFFRACTION (1.149 Å)