5ODV

Structure of Watermelon mosaic virus potyvirus.

5ODV の概要

• エントリーDOI: 10.2210/pdb5odv/pdb
• EMDBエントリー: 3785
• 分子名称: coat protein, RNA (5'-R(P*UP*UP*UP*UP*U)-3') (2 entities in total)
• 機能のキーワード: filamentous virus, potyvirus, plant pathogen, virus
• 由来する生物種: Watermelon mosaic virus; 詳細
• タンパク質・核酸の鎖数: 48
• 化学式量合計: 790782.82

構造登録者

Zamora, M.,Mendez-Lopez, E.,Agirrezabala, X.,Cuesta, R.,Lavin, J.L.,Sanchez-Pina, M.A.,Aranda, M.,Valle, M. (登録日: 2017-07-06, 公開日: 2017-09-27, 最終更新日: 2024-05-15)

主引用文献

Zamora, M.,Mendez-Lopez, E.,Agirrezabala, X.,Cuesta, R.,Lavin, J.L.,Sanchez-Pina, M.A.,Aranda, M.A.,Valle, M.
Potyvirus virion structure shows conserved protein fold and RNA binding site in ssRNA viruses.
Sci Adv, 3:eaao2182-eaao2182, 2017

PubMed Abstract: Potyviruses constitute the second largest genus of plant viruses and cause important economic losses in a large variety of crops; however, the atomic structure of their particles remains unknown. Infective potyvirus virions are long flexuous filaments where coat protein (CP) subunits assemble in helical mode bound to a monopartite positive-sense single-stranded RNA [(+)ssRNA] genome. We present the cryo-electron microscopy (cryoEM) structure of the potyvirus watermelon mosaic virus at a resolution of 4.0 Å. The atomic model shows a conserved fold for the CPs of flexible filamentous plant viruses, including a universally conserved RNA binding pocket, which is a potential target for antiviral compounds. This conserved fold of the CP is widely distributed in eukaryotic viruses and is also shared by nucleoproteins of enveloped viruses with segmented (-)ssRNA (negative-sense ssRNA) genomes, including influenza viruses.

PubMed: 28948231
DOI: 10.1126/sciadv.aao2182

実験手法

ELECTRON MICROSCOPY (4 Å)