5ODD

HUMAN MED26 N-TERMINAL DOMAIN (1-92)

「2MZO」から置き換えられました

5ODD の概要

• エントリーDOI: 10.2210/pdb5odd/pdb
• NMR情報: BMRB: 25493
• 分子名称: Mediator of RNA polymerase II transcription subunit 26 (1 entity in total)
• 機能のキーワード: mediator complex transcriptional regulation, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 10557.28

構造登録者

Lens, Z.,Cantrelle, F.-X.,Perruzini, R.,Dewitte, F.,Hanoulle, X.,Villeret, V.,Verger, A.,Landrieu, I. (登録日: 2017-07-05, 公開日: 2017-11-29, 最終更新日: 2024-06-19)

主引用文献

Peruzzini, R.,Lens, Z.,Verger, A.,Dewitte, F.,Ferreira, E.,Baert, J.L.,Villeret, V.,Landrieu, I.,Cantrelle, F.X.
1H, 15N and 13C assignments of the N-terminal domain of the Mediator complex subunit MED26.
Biomol.Nmr Assign., 10:233-236, 2016

PubMed Abstract: MED26 is a subunit of the Mediator, a very large complex involved in regulation of gene transcription by RNA Polymerase II. MED26 regulates the switch between initiation and elongation phases of the transcription. This function requires interaction of its N-terminal domain (NTD) with several protein partners implicated in transcriptional regulation. Molecular details of the structure and interaction mode of MED26 NTD would improve understanding of this complex regulation. As a first step towards structural characterization, sequence specific (1)H, (13)C and (15)N assignments for MED26 NTD was performed based on Nuclear Magnetic Resonance spectroscopy. TALOS+ analysis of the chemical shifts data revealed a domain solely composed of helices. Assignments will be further used to solve NMR structure and dynamics of MED26 NTD and investigate the molecular details of its interaction with protein partners.

PubMed: 26861138
DOI: 10.1007/s12104-016-9673-z

実験手法

SOLUTION NMR