5OD7
Hsp90 inhibitor desolvation as a rationale to steer on-rates and impact residence time
5OD7 の概要
エントリーDOI | 10.2210/pdb5od7/pdb |
分子名称 | Heat shock protein HSP 90-alpha, [2-azanyl-6-[2-(4-methylpiperazin-1-yl)sulfonylphenyl]quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone (3 entities in total) |
機能のキーワード | heat-shock protein complex, hsp90, atpase, pyrazole, chaperone, atp-binding, heat shock, nucleotide-binding, phosphorylation |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 26242.45 |
構造登録者 | Schuetz, D.A.,Richter, L.,Amaral, M.,Grandits, M.,Musil, D.,Graedler, U.,Buchstaller, H.-P.,Eggenweiler, H.-M.,Frech, M.,Ecker, G.F.,Lehmann, M. (登録日: 2017-07-04, 公開日: 2018-11-21, 最終更新日: 2024-05-08) |
主引用文献 | Schuetz, D.A.,Richter, L.,Amaral, M.,Grandits, M.,Gradler, U.,Musil, D.,Buchstaller, H.P.,Eggenweiler, H.M.,Frech, M.,Ecker, G.F. Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors. J.Med.Chem., 61:4397-4411, 2018 Cited by PubMed: 29701469DOI: 10.1021/acs.jmedchem.8b00080 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
構造検証レポート
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