5OD0

Crystal structure of ACPA E4

Summary for 5OD0

• Entry DOI: 10.2210/pdb5od0/pdb
• Descriptor: Fab fragment of ACPA E4 - Light chain, Fab fragment of ACPA E4 - heavy chain, GLYCEROL, ... (4 entities in total)
• Functional Keywords: anti-citrullinated protein antibody fab fragment, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 46970.32

Authors

Dobritzsch, D.,Ge, C.,Holmdahl, R. (deposition date: 2017-07-04, release date: 2018-07-04, Last modification date: 2024-10-16)

Primary citation

Ge, C.,Xu, B.,Liang, B.,Lonnblom, E.,Lundstrom, S.L.,Zubarev, R.A.,Ayoglu, B.,Nilsson, P.,Skogh, T.,Kastbom, A.,Malmstrom, V.,Klareskog, L.,Toes, R.E.M.,Rispens, T.,Dobritzsch, D.,Holmdahl, R.
Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies.
Arthritis Rheumatol, 71:210-221, 2019

PubMed Abstract: Anti-citrullinated protein antibodies (ACPAs) develop many years before the clinical onset of rheumatoid arthritis (RA). This study was undertaken to address the molecular basis of the specificity and cross-reactivity of ACPAs from patients with RA.

PubMed: 30152126
DOI: 10.1002/art.40698

Experimental method

X-RAY DIFFRACTION (1.8 Å)