5OCX

Crystal structure of ACPA E4 in complex with CII-C-13-CIT

Summary for 5OCX

• Entry DOI: 10.2210/pdb5ocx/pdb
• Descriptor: Fab fragment anti-citrullinated protein antibody E4 - light chain, Fab fragment of anti-citrullinated protein antibody E4 - heavy chain, CII-C-13-CIT, ... (5 entities in total)
• Functional Keywords: anti-citrullinated protein antibody fab fragment, collagen type ii epitope immune system, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 48887.31

Authors

Dobritzsch, D.,Ge, C.,Holmdahl, R. (deposition date: 2017-07-04, release date: 2018-07-04, Last modification date: 2024-11-06)

Primary citation

Ge, C.,Xu, B.,Liang, B.,Lonnblom, E.,Lundstrom, S.L.,Zubarev, R.A.,Ayoglu, B.,Nilsson, P.,Skogh, T.,Kastbom, A.,Malmstrom, V.,Klareskog, L.,Toes, R.E.M.,Rispens, T.,Dobritzsch, D.,Holmdahl, R.
Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies.
Arthritis Rheumatol, 71:210-221, 2019

PubMed Abstract: Anti-citrullinated protein antibodies (ACPAs) develop many years before the clinical onset of rheumatoid arthritis (RA). This study was undertaken to address the molecular basis of the specificity and cross-reactivity of ACPAs from patients with RA.

PubMed: 30152126
DOI: 10.1002/art.40698

Experimental method

X-RAY DIFFRACTION (1.75 Å)