5O9Q

Crystal structure of ScGas2 in complex with compound 6

5O9Q の概要

• エントリーDOI: 10.2210/pdb5o9q/pdb
• 分子名称: 1,3-beta-glucanosyltransferase GAS2, beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose, (2~{R},3~{S},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-[(2~{R},3~{R},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-[(2~{R},3~{R},4~{S},5~{R},6~{R})-2-(hydroxymethyl)-3,5-bis(oxidanyl)-6-[4-(phenylmethoxymethyl)-1,2,3-triazol-1-yl]oxan-4-yl]oxy-3,5-bis(oxidanyl)oxan-4-yl]oxy-oxane-3,4,5-triol, ... (4 entities in total)
• 機能のキーワード: aspergillus fumigatus, afgel4, scgas2, transglycosylases, glucanosyltransferases, cell wall remodeling, fungal cell wall, transferase
• 由来する生物種: Saccharomyces cerevisiae S288c
• 細胞内の位置: Cell membrane ; Lipid-anchor, GPI-anchor : Q06135
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 63606.07

構造登録者

Delso, I.,Valero-Gonzalez, J.,Gomollon-Bel, F.,Castro-Lopez, J.,Fang, W.,Navratilova, I.,Van Aalten, D.,Tejero, T.,Merino, P.,Hurtado-Guerrero, R. (登録日: 2017-06-20, 公開日: 2018-05-02, 最終更新日: 2024-01-17)

• 主引用文献: Delso, I.,Valero-Gonzalez, J.,Gomollon-Bel, F.,Castro-Lopez, J.,Fang, W.,Navratilova, I.,van Aalten, D.M.F.,Tejero, T.,Merino, P.,Hurtado-Guerrero, R.; Inhibitors against Fungal Cell Wall Remodeling Enzymes.; ChemMedChem, 13:128-132, 2018; PubMed: 29164827; DOI: 10.1002/cmdc.201700720

実験手法

X-RAY DIFFRACTION (1.4 Å)