5O5D

Cellobiohydrolase Cel7A from T. atroviride

5O5D の概要

• エントリーDOI: 10.2210/pdb5o5d/pdb
• 分子名称: Glucanase, 2-acetamido-2-deoxy-beta-D-glucopyranose, NICKEL (II) ION, ... (8 entities in total)
• 機能のキーワード: hydrolase, glycoside hydrolase, cellobiohydrolase, cellulase
• 由来する生物種: Hypocrea atroviridis (strain ATCC 20476 / IMI 206040)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 92943.26

構造登録者

Borisova, A.S.,Stahlberg, J.,Hansson, H. (登録日: 2017-06-01, 公開日: 2018-01-31, 最終更新日: 2024-11-06)

主引用文献

Borisova, A.S.,Eneyskaya, E.V.,Jana, S.,Badino, S.F.,Kari, J.,Amore, A.,Karlsson, M.,Hansson, H.,Sandgren, M.,Himmel, M.E.,Westh, P.,Payne, C.M.,Kulminskaya, A.A.,Stahlberg, J.
Correlation of structure, function and protein dynamics in GH7 cellobiohydrolases from Trichoderma atroviride, T. reesei and T. harzianum.
Biotechnol Biofuels, 11:5-5, 2018

PubMed Abstract: The ascomycete fungus is the predominant source of enzymes for industrial conversion of lignocellulose. Its glycoside hydrolase family 7 cellobiohydrolase (GH7 CBH) Cel7A constitutes nearly half of the enzyme cocktail by weight and is the major workhorse in the cellulose hydrolysis process. The orthologs from (Cel7A) and (Cel7A) show high sequence identity with Cel7A, ~ 80%, and represent naturally evolved combinations of cellulose-binding tunnel-enclosing loop motifs, which have been suggested to influence intrinsic cellobiohydrolase properties, such as endo-initiation, processivity, and off-rate.

PubMed: 29344086
DOI: 10.1186/s13068-017-1006-7

実験手法

X-RAY DIFFRACTION (1.72 Å)