5O56

Glycogen Phosphorylase b in complex with 29b

Summary for 5O56

• Entry DOI: 10.2210/pdb5o56/pdb
• Related: 5O50 5O52 5O54
• Descriptor: Glycogen phosphorylase, muscle form, PYRIDOXAL-5'-PHOSPHATE, (2~{R},3~{S},4~{R},5~{R},6~{R})-5-azanyl-2-(hydroxymethyl)-6-(3-naphthalen-2-yl-1~{H}-1,2,4-triazol-5-yl)oxane-3,4-diol, ... (4 entities in total)
• Functional Keywords: transferase
• Biological source: Oryctolagus cuniculus (Rabbit)
• Total number of polymer chains: 1
• Total formula weight: 98025.92

Authors

Solovou, T.G.A.,Kyriakis, E.,Stravodimos, G.A.,Kantsadi, A.L.,Chatzileontiadou, D.S.,Skamnaki, V.T.,Leonidas, D.D. (deposition date: 2017-05-31, release date: 2017-09-27, Last modification date: 2017-11-29)

• Primary citation: Bokor, E.,Kyriakis, E.,Solovou, T.G.A.,Koppany, C.,Kantsadi, A.L.,Szabo, K.E.,Szakacs, A.,Stravodimos, G.A.,Docsa, T.,Skamnaki, V.T.,Zographos, S.E.,Gergely, P.,Leonidas, D.D.,Somsak, L.; Nanomolar Inhibitors of Glycogen Phosphorylase Based on beta-d-Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study.; J. Med. Chem., 60:9251-9262, 2017; PubMed: 28925695; DOI: 10.1021/acs.jmedchem.7b01056

Experimental method

X-RAY DIFFRACTION (2.45 Å)