5O4K

Crystal structure of P450 CYP121 in complex with compound 6b.

5O4K の概要

• エントリーDOI: 10.2210/pdb5o4k/pdb
• 分子名称: Mycocyclosin synthase, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total)
• 機能のキーワード: cytochrome p450 redox inhibitor, oxidoreductase
• 由来する生物種: Mycobacterium tuberculosis CDC1551
• 細胞内の位置: Cytoplasm : P9WPP6
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44543.37

構造登録者

Levy, C.W. (登録日: 2017-05-29, 公開日: 2018-03-28, 最終更新日: 2024-01-17)

• 主引用文献: Taban, I.M.,Elshihawy, H.E.A.E.,Torun, B.,Zucchini, B.,Williamson, C.J.,Altuwairigi, D.,Ngu, A.S.T.,McLean, K.J.,Levy, C.W.,Sood, S.,Marino, L.B.,Munro, A.W.,de Carvalho, L.P.S.,Simons, C.; Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation.; J. Med. Chem., 60:10257-10267, 2017; PubMed: 29185746; DOI: 10.1021/acs.jmedchem.7b01562

実験手法

X-RAY DIFFRACTION (1.5 Å)