5O46

Crystal structure of Iristatin, a secreted salivary cystatin from the hard tick Ixodes ricinus

Summary for 5O46

• Entry DOI: 10.2210/pdb5o46/pdb
• Descriptor: Iristatin, GLYCEROL (3 entities in total)
• Functional Keywords: cystatin, protease inhibitor, tick, saliva, hydrolase inhibitor
• Biological source: Ixodes ricinus
• Total number of polymer chains: 2
• Total formula weight: 27978.17

Authors

Busa, M.,Rezacova, P.,Kotal, J.,Kotsyfakis, M.,Mares, M. (deposition date: 2017-05-26, release date: 2018-06-13, Last modification date: 2024-01-17)

• Primary citation: Kotal, J.,Stergiou, N.,Busa, M.,Chlastakova, A.,Berankova, Z.,Rezacova, P.,Langhansova, H.,Schwarz, A.,Calvo, E.,Kopecky, J.,Mares, M.,Schmitt, E.,Chmelar, J.,Kotsyfakis, M.; The structure and function of Iristatin, a novel immunosuppressive tick salivary cystatin.; Cell.Mol.Life Sci., 76:2003-2013, 2019; PubMed: 30747251; DOI: 10.1007/s00018-019-03034-3

Experimental method

X-RAY DIFFRACTION (1.76 Å)