5O3L

Paired helical filament in Alzheimer's disease brain

Summary for 5O3L

• Entry DOI: 10.2210/pdb5o3l/pdb
• EMDB information: 3741
• Descriptor: Microtubule-associated protein tau (1 entity in total)
• Functional Keywords: tau, amyloid, cross-beta, beta-helix, structural protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 10
• Total formula weight: 79401.41

Authors

Fitzpatrick, A.W.P.,Falcon, B.,He, S.,Murzin, A.G.,Murshudov, G.,Garringer, H.G.,Crowther, R.A.,Ghetti, B.,Goedert, M.,Scheres, S.H.W. (deposition date: 2017-05-24, release date: 2017-07-26, Last modification date: 2019-07-24)

• Primary citation: Fitzpatrick, A.W.P.,Falcon, B.,He, S.,Murzin, A.G.,Murshudov, G.,Garringer, H.J.,Crowther, R.A.,Ghetti, B.,Goedert, M.,Scheres, S.H.W.; Cryo-EM structures of tau filaments from Alzheimer's disease.; Nature, 547:185-190, 2017; PubMed: 28678775; DOI: 10.1038/nature23002

Experimental method

ELECTRON MICROSCOPY (3.4 Å)