5O22
E. coli FolD in complex with carolacton
Summary for 5O22
| Entry DOI | 10.2210/pdb5o22/pdb |
| Descriptor | Bifunctional protein FolD, Carolacton, ... (6 entities in total) |
| Functional Keywords | carolacton, fold, natural product, inhibitor, oxidoreductase |
| Biological source | Escherichia coli (strain K12) More |
| Total number of polymer chains | 4 |
| Total formula weight | 126579.48 |
| Authors | Koehnke, J.,Sikandar, A. (deposition date: 2017-05-19, release date: 2018-02-28, Last modification date: 2024-01-17) |
| Primary citation | Fu, C.,Sikandar, A.,Donner, J.,Zaburannyi, N.,Herrmann, J.,Reck, M.,Wagner-Dobler, I.,Koehnke, J.,Muller, R. The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD. Nat Commun, 8:1529-1529, 2017 Cited by PubMed: 29142318DOI: 10.1038/s41467-017-01671-5 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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