5O0Z
Structure of laspartomycin C in complex with geranyl-phosphate
Summary for 5O0Z
| Entry DOI | 10.2210/pdb5o0z/pdb |
| Related PRD ID | PRD_002234 |
| Descriptor | Laspartomycin C, [(~{E})-3-methylhex-2-enyl] dihydrogen phosphate, CALCIUM ION, ... (6 entities in total) |
| Functional Keywords | antibiotic complex, antibiotic |
| Biological source | Streptomyces viridochromogenes |
| Total number of polymer chains | 2 |
| Total formula weight | 3297.09 |
| Authors | Vlieg, H.C.,Kleijn, L.H.J.,Martin, N.I.,Janssen, B.J.C. (deposition date: 2017-05-17, release date: 2017-11-15, Last modification date: 2024-08-07) |
| Primary citation | Kleijn, L.H.J.,Vlieg, H.C.,Wood, T.M.,Sastre Torano, J.,Janssen, B.J.C.,Martin, N.I. A High-Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium-Dependent Lipopeptide Antibiotic Laspartomycin C. Angew. Chem. Int. Ed. Engl., 56:16546-16549, 2017 Cited by PubMed Abstract: The calcium-dependent antibiotics (CDAs) are an important emerging class of antibiotics. The crystal structure of the CDA laspartomycin C in complex with calcium and the ligand geranyl-phosphate at a resolution of 1.28 Å is reported. This is the first crystal structure of a CDA bound to its bacterial target. The structure is also the first to be reported for an antibiotic that binds the essential bacterial phospholipid undecaprenyl phosphate (C -P). These structural insights are of great value in the design of antibiotics capable of exploiting this unique bacterial target. PubMed: 29108098DOI: 10.1002/anie.201709240 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.28 Å) |
Structure validation
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