5O0Z

Structure of laspartomycin C in complex with geranyl-phosphate

5O0Z の概要

• エントリーDOI: 10.2210/pdb5o0z/pdb
• 関連するBIRD辞書のPRD_ID: PRD_002234
• 分子名称: Laspartomycin C, [(~{E})-3-methylhex-2-enyl] dihydrogen phosphate, CALCIUM ION, ... (6 entities in total)
• 機能のキーワード: antibiotic complex, antibiotic
• 由来する生物種: Streptomyces viridochromogenes
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 3297.09

構造登録者

Vlieg, H.C.,Kleijn, L.H.J.,Martin, N.I.,Janssen, B.J.C. (登録日: 2017-05-17, 公開日: 2017-11-15, 最終更新日: 2024-08-07)

主引用文献

Kleijn, L.H.J.,Vlieg, H.C.,Wood, T.M.,Sastre Torano, J.,Janssen, B.J.C.,Martin, N.I.
A High-Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium-Dependent Lipopeptide Antibiotic Laspartomycin C.
Angew. Chem. Int. Ed. Engl., 56:16546-16549, 2017

PubMed Abstract: The calcium-dependent antibiotics (CDAs) are an important emerging class of antibiotics. The crystal structure of the CDA laspartomycin C in complex with calcium and the ligand geranyl-phosphate at a resolution of 1.28 Å is reported. This is the first crystal structure of a CDA bound to its bacterial target. The structure is also the first to be reported for an antibiotic that binds the essential bacterial phospholipid undecaprenyl phosphate (C -P). These structural insights are of great value in the design of antibiotics capable of exploiting this unique bacterial target.

PubMed: 29108098
DOI: 10.1002/anie.201709240

実験手法

X-RAY DIFFRACTION (1.28 Å)