5NYH

Crystal Structure of Hsp90-alpha N-Domain in complex with Indazole derivative

Summary for 5NYH

Entry DOI	10.2210/pdb5nyh/pdb
Related	5NYD
Descriptor	Heat shock protein HSP 90-alpha, ~{N}-methyl-~{N}-(4-morpholin-4-ylphenyl)-6-oxidanyl-3-pyrrolidin-1-ylcarbonyl-2~{H}-indazole-5-carboxamide (3 entities in total)
Functional Keywords	chaperone
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	26163.32
Authors	Amaral, M. (deposition date: 2017-05-11, release date: 2018-04-18, Last modification date: 2024-05-08)
Primary citation	Schuetz, D.A.,Richter, L.,Amaral, M.,Grandits, M.,Gradler, U.,Musil, D.,Buchstaller, H.P.,Eggenweiler, H.M.,Frech, M.,Ecker, G.F. Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors. J. Med. Chem., 61:4397-4411, 2018 Cited by PubMed: 29701469 DOI: 10.1021/acs.jmedchem.8b00080 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation