5NV7

Human DNMT3B PWWP domain in complex with N1-(2-hydroxyethyl)-2-methyl-1,2-propanediamine

5NV7 の概要

• エントリーDOI: 10.2210/pdb5nv7/pdb
• 分子名称: DNA (cytosine-5)-methyltransferase 3B, N1-(2-hydroxyethyl)-2-methyl-1,2-propanediamine, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: dnmt3b pwwp domain, histone binding, beta barrel, ligand, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34142.41

構造登録者

Rondelet, G.,Wouters, J. (登録日: 2017-05-03, 公開日: 2018-05-30, 最終更新日: 2024-01-17)

• 主引用文献: Rondelet, G.,Dal Maso, T.,Maniquet, A.,Themans, Q.,Wouters, J.; Targeting PWWP domain of DNA methyltransferase 3B for epigenetic cancer therapy: Identification and structural characterization of new potential protein-protein interaction inhibitors; To be published,

実験手法

X-RAY DIFFRACTION (2.568 Å)