5NOU
Structure of cyclophilin A in complex with hexahydropyrimidin-2-one
Summary for 5NOU
Entry DOI | 10.2210/pdb5nou/pdb |
Descriptor | Peptidyl-prolyl cis-trans isomerase A, 1,3-diazinan-2-one, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total) |
Functional Keywords | ligand complex, beta barrel, prolyl cis/trans isomerase, cytosolic, isomerase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P62937 |
Total number of polymer chains | 1 |
Total formula weight | 18459.00 |
Authors | Georgiou, C.,Mcnae, I.W.,Ioannidis, H.,Julien, M.,Walkinshaw, M.D. (deposition date: 2017-04-13, release date: 2017-07-12, Last modification date: 2024-01-17) |
Primary citation | Georgiou, C.,McNae, I.,Wear, M.,Ioannidis, H.,Michel, J.,Walkinshaw, M. Pushing the Limits of Detection of Weak Binding Using Fragment-Based Drug Discovery: Identification of New Cyclophilin Binders. J. Mol. Biol., 429:2556-2570, 2017 Cited by PubMed: 28673552DOI: 10.1016/j.jmb.2017.06.016 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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