5NK2

Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 2b

5NK2 の概要

• エントリーDOI: 10.2210/pdb5nk2/pdb
• 分子名称: Ephrin type-A receptor 2, ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[[(3~{R},4~{R})-3-fluoranylpiperidin-4-yl]carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: inhibitor, complex, protein tyrosine kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35012.88

構造登録者

Kudlinzki, D.,Linhard, V.L.,Witt, K.,Gande, S.L.,Saxena, K.,Heinzlmeir, S.,Medard, G.,Kuester, B.,Schwalbe, H. (登録日: 2017-03-31, 公開日: 2017-06-07, 最終更新日: 2024-01-17)

• 主引用文献: Heinzlmeir, S.,Lohse, J.,Treiber, T.,Kudlinzki, D.,Linhard, V.,Gande, S.L.,Sreeramulu, S.,Saxena, K.,Liu, X.,Wilhelm, M.,Schwalbe, H.,Kuster, B.,Medard, G.; Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.; ChemMedChem, 12:999-1011, 2017; PubMed: 28544567; DOI: 10.1002/cmdc.201700217

実験手法

X-RAY DIFFRACTION (1.649 Å)