5NJH

Triazolopyrimidines stabilize microtubules by binding to the vinca inhibitor site of tubulin

Summary for 5NJH

Entry DOI	10.2210/pdb5njh/pdb
Descriptor	Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ... (10 entities in total)
Functional Keywords	tubulin, microtubules, microtubule targeting agents, antitumoural, resistance to chemotherapy, structural protein
Biological source	Rattus norvegicus (Rat) More
Cellular location	Cytoplasm, cytoskeleton: P81947 Q6B856 Golgi apparatus : P63043
Total number of polymer chains	6
Total formula weight	264288.29
Authors	Sharma, A.,Calvo, G.S.,Prota, A.E.,Diaz, J.F.,Steinmetz, M.O. (deposition date: 2017-03-28, release date: 2017-06-21, Last modification date: 2024-01-17)
Primary citation	Saez-Calvo, G.,Sharma, A.,Balaguer, F.A.,Barasoain, I.,Rodriguez-Salarichs, J.,Olieric, N.,Munoz-Hernandez, H.,Berbis, M.A.,Wendeborn, S.,Penalva, M.A.,Matesanz, R.,Canales, A.,Prota, A.E.,Jimenez-Barbero, J.,Andreu, J.M.,Lamberth, C.,Steinmetz, M.O.,Diaz, J.F. Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin. Cell Chem Biol, 24:737-750.e6, 2017 Cited by PubMed: 28579361 DOI: 10.1016/j.chembiol.2017.05.016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.394 Å)

Structure validation