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5NJ6

Crystal structure of a thermostabilised human protease-activated receptor-2 (PAR2) in ternary complex with Fab3949 and AZ7188 at 4.0 angstrom resolution

Summary for 5NJ6
Entry DOI10.2210/pdb5nj6/pdb
DescriptorProteinase-activated receptor 2,Soluble cytochrome b562,Proteinase-activated receptor 2, Fab3949 H, Fab3949 L (3 entities in total)
Functional Keywordsmembrane protein, gpcr, 7tm
Biological sourceHomo sapiens (Human)
More
Cellular locationCell membrane; Multi-pass membrane protein: P55085
Total number of polymer chains3
Total formula weight96125.70
Authors
Primary citationCheng, R.K.Y.,Fiez-Vandal, C.,Schlenker, O.,Edman, K.,Aggeler, B.,Brown, D.G.,Brown, G.A.,Cooke, R.M.,Dumelin, C.E.,Dore, A.S.,Geschwindner, S.,Grebner, C.,Hermansson, N.O.,Jazayeri, A.,Johansson, P.,Leong, L.,Prihandoko, R.,Rappas, M.,Soutter, H.,Snijder, A.,Sundstrom, L.,Tehan, B.,Thornton, P.,Troast, D.,Wiggin, G.,Zhukov, A.,Marshall, F.H.,Dekker, N.
Structural insight into allosteric modulation of protease-activated receptor 2.
Nature, 545:112-115, 2017
Cited by
PubMed: 28445455
DOI: 10.1038/nature22309
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (4 Å)
Structure validation

217705

數據於2024-03-27公開中

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