5NI5
Ligand complex of RORg LBD
Summary for 5NI5
Entry DOI | 10.2210/pdb5ni5/pdb |
Descriptor | Nuclear receptor ROR-gamma, tethered SRC2-2 peptide, ~{N}-[4-(3-chlorophenyl)-5-(2-chlorophenyl)carbonyl-1,3-thiazol-2-yl]-2-(4-ethylsulfonylphenyl)ethanamide, ... (5 entities in total) |
Functional Keywords | rar-related orphan receptor-g (rorg), transcription, rorg ligand, structure-based design |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 35675.73 |
Authors | Xue, Y.,Aagaard, A.,Narjes, F. (deposition date: 2017-03-23, release date: 2018-08-22, Last modification date: 2024-01-17) |
Primary citation | Narjes, F.,Xue, Y.,von Berg, S.,Malmberg, J.,Llinas, A.,Olsson, R.I.,Jirholt, J.,Grindebacke, H.,Leffler, A.,Hossain, N.,Lepisto, M.,Thunberg, L.,Leek, H.,Aagaard, A.,McPheat, J.,Hansson, E.L.,Back, E.,Tangefjord, S.,Chen, R.,Xiong, Y.,Hongbin, G.,Hansson, T.G. Potent and Orally Bioavailable Inverse Agonists of ROR gamma t Resulting from Structure-Based Design. J. Med. Chem., 61:7796-7813, 2018 Cited by PubMed: 30095900DOI: 10.1021/acs.jmedchem.8b00783 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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