5NHY
BAY-707 in complex with MTH1
Summary for 5NHY
Entry DOI | 10.2210/pdb5nhy/pdb |
Descriptor | 7,8-dihydro-8-oxoguanine triphosphatase, ~{N}-ethyl-4-[(3~{S})-3-methylmorpholin-4-yl]-1~{H}-pyrrolo[2,3-b]pyridine-2-carboxamide, SULFATE ION, ... (5 entities in total) |
Functional Keywords | nudix, nucleotide hydrolase, inhibitor, oncology, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Isoform p18: Cytoplasm. Isoform p26: Cytoplasm: P36639 |
Total number of polymer chains | 2 |
Total formula weight | 38032.89 |
Authors | Ellermann, M.,Eheim, A.,Giese, A.,Bunse, S.,Nowak-Reppel, K.,Neuhaus, R.,Weiske, J.,Quanz, M.,Glasauer, A.,Meyer, H.,Queisser, N.,Irlbacher, H.,Bader, B.,Rahm, F.,Viklund, J.,Andersson, M.,Ericsson, U.,Ginman, T.,Forsblom, R.,Lindstrom, J.,Silvander, C.,Tresaugues, L.,Gorjanacz, M. (deposition date: 2017-03-22, release date: 2017-07-19, Last modification date: 2024-01-17) |
Primary citation | Ellermann, M.,Eheim, A.,Rahm, F.,Viklund, J.,Guenther, J.,Andersson, M.,Ericsson, U.,Forsblom, R.,Ginman, T.,Lindstrom, J.,Silvander, C.,Tresaugues, L.,Giese, A.,Bunse, S.,Neuhaus, R.,Weiske, J.,Quanz, M.,Glasauer, A.,Nowak-Reppel, K.,Bader, B.,Irlbacher, H.,Meyer, H.,Queisser, N.,Bauser, M.,Haegebarth, A.,Gorjanacz, M. Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target. ACS Chem. Biol., 12:1986-1992, 2017 Cited by PubMed: 28679043DOI: 10.1021/acschembio.7b00370 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.72 Å) |
Structure validation
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