5NHO

Human Erk2 with an Erk1/2 inhibitor

5NHO の概要

• エントリーDOI: 10.2210/pdb5nho/pdb
• 分子名称: Mitogen-activated protein kinase 1, SULFATE ION, (6~{S})-5-(2-methoxyethyl)-6-methyl-2-[5-methyl-2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-6,7-dihydro-1~{H}-pyrrolo[3,2-c]pyridin-4-one, ... (4 entities in total)
• 機能のキーワード: erk2, kinase, inhibitor, oncology, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm, cytoskeleton, spindle : P28482
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44400.82

構造登録者

Debreczeni, J.E.,Ward, R.A.,Bethel, P.,Cook, C.,Davies, E.,Eckersley, K.,Fairley, G.,Feron, L.,Flemington, V.,Graham, M.A.,Greenwood, R.,Hopcroft, P.,Howard, T.D.,Hudson, J.,James, M.,Jones, C.D.,Jones, C.R.,Lamont, S.,Lewis, R.,Lindsay, N.,Roberts, K.,Simpson, I.,StGallay, S.,Swallow, S.,Tonge, M. (登録日: 2017-03-22, 公開日: 2017-04-19, 最終更新日: 2024-05-08)

• 主引用文献: Ward, R.A.,Bethel, P.,Cook, C.,Davies, E.,Debreczeni, J.E.,Fairley, G.,Feron, L.,Flemington, V.,Graham, M.A.,Greenwood, R.,Griffin, N.,Hanson, L.,Hopcroft, P.,Howard, T.D.,Hudson, J.,James, M.,Jones, C.D.,Jones, C.R.,Lamont, S.,Lewis, R.,Lindsay, N.,Roberts, K.,Simpson, I.,St-Gallay, S.,Swallow, S.,Tang, J.,Tonge, M.,Wang, Z.,Zhai, B.; Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point.; J. Med. Chem., 60:3438-3450, 2017; PubMed: 28376306; DOI: 10.1021/acs.jmedchem.7b00267

実験手法

X-RAY DIFFRACTION (2.24 Å)