5NGF
Crystal structure of USP7 in complex with the covalent inhibitor, FT827
Summary for 5NGF
Entry DOI | 10.2210/pdb5ngf/pdb |
Descriptor | Ubiquitin carboxyl-terminal hydrolase 7, ~{N}-[2-[4-[4-[(1-methyl-4-oxidanylidene-pyrazolo[3,4-d]pyrimidin-5-yl)methyl]-4-oxidanyl-piperidin-1-yl]carbonylphenyl]phenyl]ethanesulfonamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | deubiquitination, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : Q93009 |
Total number of polymer chains | 2 |
Total formula weight | 83460.27 |
Authors | Krajewski, W.W.,Turnbull, A.P.,Ioannidis, S.,Kessler, B.M.,Komander, D. (deposition date: 2017-03-17, release date: 2017-10-18, Last modification date: 2024-01-17) |
Primary citation | Turnbull, A.P.,Ioannidis, S.,Krajewski, W.W.,Pinto-Fernandez, A.,Heride, C.,Martin, A.C.L.,Tonkin, L.M.,Townsend, E.C.,Buker, S.M.,Lancia, D.R.,Caravella, J.A.,Toms, A.V.,Charlton, T.M.,Lahdenranta, J.,Wilker, E.,Follows, B.C.,Evans, N.J.,Stead, L.,Alli, C.,Zarayskiy, V.V.,Talbot, A.C.,Buckmelter, A.J.,Wang, M.,McKinnon, C.L.,Saab, F.,McGouran, J.F.,Century, H.,Gersch, M.,Pittman, M.S.,Marshall, C.G.,Raynham, T.M.,Simcox, M.,Stewart, L.M.D.,McLoughlin, S.B.,Escobedo, J.A.,Bair, K.W.,Dinsmore, C.J.,Hammonds, T.R.,Kim, S.,Urbe, S.,Clague, M.J.,Kessler, B.M.,Komander, D. Molecular basis of USP7 inhibition by selective small-molecule inhibitors. Nature, 550:481-486, 2017 Cited by PubMed: 29045389DOI: 10.1038/nature24451 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.33 Å) |
Structure validation
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