5NFT

Glucocorticoid Receptor in complex with AZD5423

5NFT の概要

• エントリーDOI: 10.2210/pdb5nft/pdb
• 分子名称: Glucocorticoid receptor, Nuclear receptor coactivator 2, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: glucocorticoid receptor, nuclear hormone receptor, steroid receptor, ligand complex, peptide complex, hormone
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Isoform Alpha: Cytoplasm . Isoform Beta: Nucleus . Isoform Alpha-B: Nucleus : P04150; Nucleus: Q15596
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34412.55

構造登録者

Edman, K.,Wissler, L. (登録日: 2017-03-15, 公開日: 2017-10-04, 最終更新日: 2024-01-17)

• 主引用文献: Hemmerling, M.,Nilsson, S.,Edman, K.,Eirefelt, S.,Russell, W.,Hendrickx, R.,Johnsson, E.,Karrman Mardh, C.,Berger, M.,Rehwinkel, H.,Abrahamsson, A.,Dahmen, J.,Eriksson, A.R.,Gabos, B.,Henriksson, K.,Hossain, N.,Ivanova, S.,Jansson, A.H.,Jensen, T.J.,Jerre, A.,Johansson, H.,Klingstedt, T.,Lepisto, M.,Lindsjo, M.,Mile, I.,Nikitidis, G.,Steele, J.,Tehler, U.,Wissler, L.,Hansson, T.; Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases.; J. Med. Chem., 60:8591-8605, 2017; PubMed: 28937774; DOI: 10.1021/acs.jmedchem.7b01215

実験手法

X-RAY DIFFRACTION (2.3 Å)