5NEA

Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-(2-methyl-1,3-oxazol-5-yl)benzene-1-sulfonammide

5NEA の概要

• エントリーDOI: 10.2210/pdb5nea/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, 4-(2-methyl-1,3-oxazol-5-yl)benzenesulfonamide, ... (6 entities in total)
• 機能のキーワード: lyase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29985.16

構造登録者

Ferraroni, M.,Supuran, C.T.,Krasavin, M. (登録日: 2017-03-10, 公開日: 2017-12-06, 最終更新日: 2024-01-17)

• 主引用文献: Ferraroni, M.,Lucarini, L.,Masini, E.,Korsakov, M.,Scozzafava, A.,Supuran, C.T.,Krasavin, M.; 1,3-Oxazole-based selective picomolar inhibitors of cytosolic human carbonic anhydrase II alleviate ocular hypertension in rabbits: Potency is supported by X-ray crystallography of two leads.; Bioorg. Med. Chem., 25:4560-4565, 2017; PubMed: 28728897; DOI: 10.1016/j.bmc.2017.06.054

実験手法

X-RAY DIFFRACTION (1.3 Å)