5NE1

L2 class A serine-beta-lactamase in complex with cyclic boronate 2

5NE1 の概要

• エントリーDOI: 10.2210/pdb5ne1/pdb
• 分子名称: Beta-lactamase, TRIETHYLENE GLYCOL, (4~{R})-4-[[4-(aminomethyl)phenyl]carbonylamino]-3,3-bis(oxidanyl)-2-oxa-3-boranuidabicyclo[4.4.0]deca-1(10),6,8-triene-10-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: beta-lactamase, carbapenemase, cyclic boronate, inhibitor, hydrolase
• 由来する生物種: Stenotrophomonas maltophilia (Pseudomonas maltophilia)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 59143.77

構造登録者

Hinchliffe, P.,Calvopina, K.,Spencer, J. (登録日: 2017-03-09, 公開日: 2017-09-13, 最終更新日: 2024-01-17)

• 主引用文献: Calvopina, K.,Hinchliffe, P.,Brem, J.,Heesom, K.J.,Johnson, S.,Cain, R.,Lohans, C.T.,Fishwick, C.W.G.,Schofield, C.J.,Spencer, J.,Avison, M.B.; Structural/mechanistic insights into the efficacy of nonclassical beta-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates.; Mol. Microbiol., 106:492-504, 2017; PubMed: 28876489; DOI: 10.1111/mmi.13831

実験手法

X-RAY DIFFRACTION (2.09 Å)