5NAW
Complement factor D in complex with the inhibitor (1R,3S,5R)-2-Aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid 2-[(1-carbamoyl-1H-indol-3-yl)-amide] 3-[(3-trifluoromethoxy-phenyl)-amide]
Summary for 5NAW
Entry DOI | 10.2210/pdb5naw/pdb |
Descriptor | Complement factor D, (1~{R},3~{S},5~{R})-~{N}2-(1-aminocarbonylindol-3-yl)-~{N}3-[3-(trifluoromethyloxy)phenyl]-2-azabicyclo[3.1.0]hexane-2,3-dicarboxamide (3 entities in total) |
Functional Keywords | hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted: P00746 |
Total number of polymer chains | 1 |
Total formula weight | 25226.55 |
Authors | Mac Sweeney, A.,Ostermann, N. (deposition date: 2017-02-28, release date: 2017-06-28, Last modification date: 2024-05-01) |
Primary citation | Lorthiois, E.,Anderson, K.,Vulpetti, A.,Rogel, O.,Cumin, F.,Ostermann, N.,Steinbacher, S.,Mac Sweeney, A.,Delgado, O.,Liao, S.M.,Randl, S.,Rudisser, S.,Dussauge, S.,Fettis, K.,Kieffer, L.,de Erkenez, A.,Yang, L.,Hartwieg, C.,Argikar, U.A.,La Bonte, L.R.,Newton, R.,Kansara, V.,Flohr, S.,Hommel, U.,Jaffee, B.,Maibaum, J. Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo. J. Med. Chem., 60:5717-5735, 2017 Cited by PubMed: 28621538DOI: 10.1021/acs.jmedchem.7b00425 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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