5NAU

Torpedo californica acetylcholinesterase in complex with a non-chiral donepezil-like compound 20

5NAU の概要

• エントリーDOI: 10.2210/pdb5nau/pdb
• 分子名称: Acetylcholinesterase, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: alzheimer's disease, acetylcholinesterase, donepezil analogues, green chemistry, hydrolase
• 由来する生物種: Tetronarce californica (Pacific electric ray)
• 細胞内の位置: Isoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 63537.25

構造登録者

Caliandro, R.,Pesaresi, A.,Lamba, D. (登録日: 2017-02-28, 公開日: 2018-05-02, 最終更新日: 2020-07-29)

• 主引用文献: Caliandro, R.,Pesaresi, A.,Cariati, L.,Procopio, A.,Oliverio, M.,Lamba, D.; Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid analogues.; J Enzyme Inhib Med Chem, 33:794-803, 2018; PubMed: 29651884; DOI: 10.1080/14756366.2018.1458030

実験手法

X-RAY DIFFRACTION (2.25 Å)