5NAD

TTK kinase domain in complex with BAY 1217389

Summary for 5NAD

Entry DOI	10.2210/pdb5nad/pdb
Related	5N7V
Descriptor	Dual specificity protein kinase TTK, BAY 1217389 (3 entities in total)
Functional Keywords	kinase, inhibitor, mitosis, mps1, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	36772.78
Authors	Uitdehaag, J.C.M.,Willemsen-Seegers, N.,Sterrenburg, J.G.,de Man, J.,Buijsman, R.C.,Zaman, G.J.R. (deposition date: 2017-02-27, release date: 2017-05-31, Last modification date: 2024-01-17)
Primary citation	Uitdehaag, J.C.M.,de Man, J.,Willemsen-Seegers, N.,Prinsen, M.B.W.,Libouban, M.A.A.,Sterrenburg, J.G.,de Wit, J.J.P.,de Vetter, J.R.F.,de Roos, J.A.D.M.,Buijsman, R.C.,Zaman, G.J.R. Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity. J. Mol. Biol., 429:2211-2230, 2017 Cited by PubMed: 28539250 DOI: 10.1016/j.jmb.2017.05.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation