5N9L

Crystal structure of human Protein kinase CK2 catalytic subunit in complex with the ATP-competitive dibenzofuran inhibitor TF (4b)

5N9L の概要

• エントリーDOI: 10.2210/pdb5n9l/pdb
• 関連するPDBエントリー: 5N9K 5N9N
• 分子名称: Casein kinase II subunit alpha, (4~{Z})-6,7-bis(chloranyl)-4-[[(4-methylphenyl)amino]methylidene]-8-oxidanyl-1,2-dihydrodibenzofuran-3-one, ACETATE ION, ... (5 entities in total)
• 機能のキーワード: protein kinase, ck2, casein kinase 2, protein phosphorylation, atp-competitive inhititors, dibenzofuran derivatives, transferase, tight-binding inhibitors
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : P68400
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40941.45

構造登録者

Schnitzler, A.,Gratz, A.,Bollacke, A.,Weyrich, M.,Kucklaender, U.,Wuensch, B.,Goetz, C.,Niefind, K.,Jose, J. (登録日: 2017-02-25, 公開日: 2018-02-28, 最終更新日: 2024-01-17)

• 主引用文献: Schnitzler, A.,Gratz, A.,Bollacke, A.,Weyrich, M.,Kucklander, U.,Wunsch, B.,Gotz, C.,Niefind, K.,Jose, J.; A pi-Halogen Bond of Dibenzofuranones with the Gatekeeper Phe113 in Human Protein Kinase CK2 Leads to Potent Tight Binding Inhibitors.; Pharmaceuticals, 11:-, 2018; PubMed: 29462988; DOI: 10.3390/ph11010023

実験手法

X-RAY DIFFRACTION (1.79 Å)