5N9K
Crystal structure of human Protein kinase CK2 catalytic subunit in complex with the ATP-competitive, tight-binding dibenzofuran inhibitor TF107 (5)
Summary for 5N9K
| Entry DOI | 10.2210/pdb5n9k/pdb |
| Related | 5N9L 5N9N |
| Descriptor | Casein kinase II subunit alpha, 1,3-bis(chloranyl)-6-[(~{E})-(4-methoxyphenyl)iminomethyl]dibenzofuran-2,7-diol, ACETATE ION, ... (5 entities in total) |
| Functional Keywords | protein kinase, ck2, casein kinase 2, protein phosphorylation, atp-competitive inhititors, dibenzofuran derivatives, transferase, tight-binding inhibitors |
| Biological source | Homo sapiens (Human) |
| Cellular location | Nucleus : P68400 |
| Total number of polymer chains | 1 |
| Total formula weight | 40915.33 |
| Authors | Schnitzler, A.,Gratz, A.,Bollacke, A.,Weyrich, M.,Kucklaender, U.,Wuensch, B.,Goetz, C.,Niefind, K.,Jose, J. (deposition date: 2017-02-25, release date: 2018-02-28, Last modification date: 2024-01-17) |
| Primary citation | Schnitzler, A.,Gratz, A.,Bollacke, A.,Weyrich, M.,Kucklander, U.,Wunsch, B.,Gotz, C.,Niefind, K.,Jose, J. A pi-Halogen Bond of Dibenzofuranones with the Gatekeeper Phe113 in Human Protein Kinase CK2 Leads to Potent Tight Binding Inhibitors. Pharmaceuticals, 11:-, 2018 Cited by PubMed: 29462988DOI: 10.3390/ph11010023 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.643 Å) |
Structure validation
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