5N93

TTK kinase domain in complex with TC-Mps1-12

Summary for 5N93

• Entry DOI: 10.2210/pdb5n93/pdb
• Related: 5N7V
• Descriptor: Dual specificity protein kinase TTK, 4-[[4-azanyl-6-(~{tert}-butylamino)-5-cyano-pyridin-2-yl]amino]benzamide (3 entities in total)
• Functional Keywords: kinase, inhibitor, mitosis, mps1, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 36535.66

Authors

Uitdehaag, J.,Willemsen-Seegers, N.,de Man, J.,Buijsman, R.C.,Zaman, G.J.R. (deposition date: 2017-02-24, release date: 2017-05-31, Last modification date: 2017-08-23)

• Primary citation: Uitdehaag, J.C.M.,de Man, J.,Willemsen-Seegers, N.,Prinsen, M.B.W.,Libouban, M.A.A.,Sterrenburg, J.G.,de Wit, J.J.P.,de Vetter, J.R.F.,de Roos, J.A.D.M.,Buijsman, R.C.,Zaman, G.J.R.; Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity.; J. Mol. Biol., 429:2211-2230, 2017; PubMed: 28539250; DOI: 10.1016/j.jmb.2017.05.014

Experimental method

X-RAY DIFFRACTION (2.1 Å)