5N68

Crystal Structure of p38alpha in Complex with Lipid Pocket Ligand 9m

5N68 の概要

• エントリーDOI: 10.2210/pdb5n68/pdb
• 分子名称: Mitogen-activated protein kinase 14, 2-(4-morpholin-4-ylphenyl)-~{N}4-(2-phenylethyl)quinazoline-4,7-diamine (3 entities in total)
• 機能のキーワード: kinase, small molecule, lipid pocket, p38, quinazoline, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41768.72

構造登録者

Buehrmann, M.,Mueller, M.P.,Rauh, D. (登録日: 2017-02-14, 公開日: 2017-09-20, 最終更新日: 2024-01-17)

• 主引用文献: Buhrmann, M.,Wiedemann, B.M.,Muller, M.P.,Hardick, J.,Ecke, M.,Rauh, D.; Structure-based design, synthesis and crystallization of 2-arylquinazolines as lipid pocket ligands of p38 alpha MAPK.; PLoS ONE, 12:e0184627-e0184627, 2017; PubMed: 28892510; DOI: 10.1371/journal.pone.0184627

実験手法

X-RAY DIFFRACTION (1.85 Å)