5N58

di-Zinc VIM-5 metallo-beta-lactamase in complex with (1-chloro-4-hydroxyisoquinoline-3-carbonyl)-D-tryptophan (Compound 1)

5N58 の概要

• エントリーDOI: 10.2210/pdb5n58/pdb
• 分子名称: Class B metallo-beta-lactamase, ZINC ION, (2~{R})-2-[(1-chloranyl-4-oxidanyl-isoquinolin-3-yl)carbonylamino]-3-(1~{H}-indol-3-yl)propanoic acid, ... (5 entities in total)
• 機能のキーワード: metallo-beta-lactamase, inhibitor, complex, antibiotic resistance, hydrolase
• 由来する生物種: Klebsiella pneumoniae
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 57337.04

構造登録者

Li, G.-B.,Brem, J.,McDonough, M.A.,Schofield, C.J. (登録日: 2017-02-13, 公開日: 2017-05-17, 最終更新日: 2024-01-17)

• 主引用文献: Li, G.B.,Brem, J.,Lesniak, R.,Abboud, M.I.,Lohans, C.T.,Clifton, I.J.,Yang, S.Y.,Jimenez-Castellanos, J.C.,Avison, M.B.,Spencer, J.,McDonough, M.A.,Schofield, C.J.; Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-beta-lactamase inhibition.; Chem. Commun. (Camb.), 53:5806-5809, 2017; PubMed: 28470248; DOI: 10.1039/c7cc02394d

実験手法

X-RAY DIFFRACTION (1.957 Å)