5N2U

Influenza D virus nucleoprotein

5N2U の概要

• エントリーDOI: 10.2210/pdb5n2u/pdb
• 分子名称: Nucleoprotein (2 entities in total)
• 機能のキーワード: influenza virus, nucleoprotein, viral protein
• 由来する生物種: Influenza D virus (D/bovine/France/2986/2012)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 245561.44

構造登録者

Labaronne, A.,Ruigrok, R.W.H.,Crepin, T. (登録日: 2017-02-08, 公開日: 2018-02-28, 最終更新日: 2024-01-17)

主引用文献

Donchet, A.,Oliva, J.,Labaronne, A.,Tengo, L.,Miloudi, M.,C A Gerard, F.,Mas, C.,Schoehn, G.,W H Ruigrok, R.,Ducatez, M.,Crepin, T.
The structure of the nucleoprotein of Influenza D shows that all Orthomyxoviridae nucleoproteins have a similar NPCORE, with or without a NPTAILfor nuclear transport.
Sci Rep, 9:600-600, 2019

PubMed Abstract: This paper focuses on the nucleoprotein (NP) of the newly identified member of the Orthomyxoviridae family, Influenza D virus. To date several X-ray structures of NP of Influenza A (A/NP) and B (B/NP) viruses and of infectious salmon anemia (ISA/NP) virus have been solved. Here we purified, characterized and solved the X-ray structure of the tetrameric D/NP at 2.4 Å resolution. The crystal structure of its core is similar to NP of other Influenza viruses. However, unlike A/NP and B/NP which possess a flexible amino-terminal tail containing nuclear localization signals (NLS) for their nuclear import, D/NP possesses a carboxy-terminal tail (D/NP). We show that D/NP harbors a bipartite NLS and designed C-terminal truncated mutants to demonstrate the role of D/NP for nuclear transport.

PubMed: 30679709
DOI: 10.1038/s41598-018-37306-y

実験手法

X-RAY DIFFRACTION (2.4 Å)