5N2S

Crystal structure of stabilized A1 receptor in complex with PSB36 at 3.3A resolution

Summary for 5N2S

Entry DOI	10.2210/pdb5n2s/pdb
Descriptor	Soluble cytochrome b562,Adenosine receptor A1, 1-butyl-3-(3-oxidanylpropyl)-8-[(1~{R},5~{S})-3-tricyclo[3.3.1.0^{3,7}]nonanyl]-7~{H}-purine-2,6-dione, SULFATE ION, ... (4 entities in total)
Functional Keywords	g-protein-coupled receptor, integral thermostabilizing mutations, membrane protein
Biological source	Escherichia coli More
Cellular location	Cell membrane ; Multi-pass membrane protein: P30542
Total number of polymer chains	1
Total formula weight	49024.47
Authors	Cheng, R.K.Y.,Segala, E.,Robertson, N.,Deflorian, F.,Dore, A.S.,Errey, J.C.,Fiez-Vandal, C.,Marshall, F.H.,Cooke, R.M. (deposition date: 2017-02-08, release date: 2017-07-26, Last modification date: 2024-01-17)
Primary citation	Cheng, R.K.Y.,Segala, E.,Robertson, N.,Deflorian, F.,Dore, A.S.,Errey, J.C.,Fiez-Vandal, C.,Marshall, F.H.,Cooke, R.M. Structures of Human A1 and A2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity. Structure, 25:1275-1285.e4, 2017 Cited by PubMed: 28712806 DOI: 10.1016/j.str.2017.06.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.303 Å)

Structure validation